Founded in 1869, OPBG has 800 beds in 6 buildings, and is a well-established comprehensive medical centre for paediatric healthcare. OPBG is accredited by the National Healthcare Service, and is one of three Paediatric Research Hospitals in Italy. The Department of Cardiology is one of the largest in Europe, with over 800 paediatric cardiac catheterizations and over 500 open-heart interventions per year. Prof. Giacomo Pongiglione, the head of the Department of Cardiology, held in the past the same position within the Istituto Giannina Gaslini in Genoa, and has been the Clinical Coordinator of Health-e-Child since its beginning. Prof. Pongiglione will be the WP leader for WP3 aligning the clinical protocol and collaborate with JHU in WP5 in the evaluation of the left heart model for congenital Aortic Arch disease.